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Freelance translator and/or interpreter, Verified member
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English to Spanish: Clinical pharmacology General field: Medical Detailed field: Medical (general)
Source text - English In theory pharmacodynamics gene testing of the serotonin transporter (SLC6A4) may help predict response and adverse effects of selective serotonin reuptake inhibitor (SSRI) and serotonin–norepinephrine reuptake inhibitor (SNRI) antidepressants.
The pharmacokinetic genes, discussed below, CYP450 (CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5), may predict rate of metabolism of medications and predict dose adjustment.
Another serotonin receptor 2C (5-HT) mutation may predict weight gain with atypical antipsychotics.
Despite the limitations and clinical utility of pharmacogenomic testing, psychiatrists should familiarize themselves with genetic terminology, genes and alleles affecting various psychotropic medications as well as understanding metabolizing factors that may impact the use of psychotropic medicines and inform the patients about potential issues and individualizing treatment choices.
Translation - Spanish En teoría, las pruebas de farmacodinámica del gen para el transportador de serotonina (SLC6A4) son capaces de predecir la respuesta y los efectos adversos derivados de la administración de antidepresivos como inhibidores selectivos de la recaptación de serotonina (ISRS) e inhibidores de la recaptación de serotonina y noradrenalina (IRSN).
Los genes farmacocinéticos que se comentan a continuación (CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5) son capaces de predecir la tasa metabólica de los medicamentos y el ajuste de dosis.
Otra mutación, en el receptor 2C de serotonina (5-HT), es capaz de predecir el aumento de peso con los antipsicóticos atípicos.
A pesar de las limitaciones y la escasa utilidad clínica de las pruebas farmacogenómicas, los psiquiatras deben estar familiarizados con la terminología genética, los genes y los alelos que afectan a diversos psicofármacos, así como comprender los factores que pueden afectar el empleo de psicofármacos, informar a los pacientes acerca de problemas potenciales e individualizar la elección del tratamiento.
English to Spanish: Clinical morphology General field: Medical Detailed field: Medical (general)
Source text - English To meet the body’s energy demands when nutrient supplies are low, adipose tissue efficiently stores excess energy. Numerous unmyelinated, noradrenergic sympathetic nerve fibers are present among the fat cells.
For example, brown adipose tissue, with its increased glucose uptake mediated by increased activity of glucose transporters, can be a potential source of false-positive interpretation of PET scans.
As lipoblastic differentiation begins, vesicles increase in number, with a corresponding decrease in rough-surfaced endoplasmic reticulum (rER).
It retains this structural function even during reduced caloric intake; when adipose tissue elsewhere becomes depleted of lipid, this structural adipose tissue remains undiminished.
The unique large, round mitochondria in the cytoplasm of brown adipose tissue cells contain uncoupling protein (UCP-1), which uncouples the oxidation of fatty acids from the production of ATP.
Brown adipose tissue, a key thermogenic tissue, is present in large amounts in the newborn, which helps to offset the extensive heat loss that results from the newborn’s high surface-to-mass ratio and to avoid lethal hypothermia (a major risk of death for preterm babies).
Translation - Spanish Para satisfacer la demanda de energía del cuerpo cuando hay escasez de alimentos, el tejido adiposo almacena con mucha eficiencia el exceso de energía. Entre los adipocitos, se hallan abundantes fibras nerviosas amielínicas adrenérgicas del sistema nervioso simpático.
Por ejemplo, el tejido adiposo pardo tiene una captación de glucosa elevada, que es mediada por una actividad elevada de los transportadores de glucosa, lo cual puede ser una fuente posible de falsos positivos en la interpretación de los resultados con este método.
A medida que se inicia la diferenciación de los lipoblastos, aumenta la cantidad de vesículas y disminuye el retículo endoplásmico rugoso (RER).
Se mantiene esta función estructural incluso durante la ingesta calórica reducida, pues cuando el tejido adiposo de otros sitios agota sus lípidos, el tejido adiposo estructural no disminuye.
Las mitocondrias peculiares grandes y redondas, que se encuentran en el citoplasma de las células del tejido adiposo pardo contienen la proteína desacoplante (UCP-1), que desacopla la oxidación de los ácidos grasos de la producción de ATP.
El tejido adiposo pardo es un tejido termógeno esencial que se encuentra presente en grandes cantidades en el neonato, lo que ayuda a protegerlo de la gran pérdida de calor que es resultado de la desfavorable relación entre su superficie y su masa, y evita la hipotermia mortal (un importante riesgo de muerte en los lactantes prematuros).
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Experience
Years of experience: 9. Registered at ProZ.com: May 2020. Became a member: May 2020.
Credentials
Spanish (Centro de Enseñanza de Lenguas Extranjeras (UNAM), verified) English (University of Glasgow, verified)
Memberships
N/A
Software
Adobe Acrobat, Adobe Illustrator, Adobe Photoshop, Google Translator Toolkit, MemSource Cloud, Microsoft Excel, Microsoft Office Pro, Microsoft Word, PhraseApp, Powerpoint
Medical doctor with broad experience in Medical Translations and Project management. I have worked with international editorial and marketing agencies providing medical translations, copyediting, and proofreading. I've also have the opportunity of managing projects related to medical education and online courses. My specialization is translation of full medical textbooks, articles for medical journals, and scientific writing and transcreation for web media.
Some of the projects that I've done (including some best sellers!):
Bickley, L., Szilagyi, P. and Hoffman, R. Bates, guía de bolsillo de exploración física e historia clínica. Hospitalet de Llobregat, Barcelona: Wolters Kluwer; 2018.
Willis, L. Colección Lippincott Enfermería. Un enfoque práctico y conciso: Anatomía y fisiología. 5 ed. Wolters Kluwer; 2018.
McLaughlin, MAS. Colección Lippincott Enfermería. Un enfoque práctico y conciso: Enfermería cardiovascular. 3 ed S.l.: Wolters Kluwer; 2018.
Zane, R. Medicina de urgencias de bolsillo. 4 ed. S.l.: Wolters Kluwer; 2018.
Weber, J. Manual de valoración de la salud en enfermería. 9 ed. S.l.: Wolters Kluwer; 2018.
Eliopoulos, C. Enfermería geriátrica y gerontológica. S.l.: Wolters Kluwer; 2019.
Keywords: medical translation, medical editor, medical writer, medical doctor, physician, clinical, Pharma, pharmacology, pharmaceuticals, medicine. See more.medical translation, medical editor, medical writer, medical doctor, physician, clinical, Pharma, pharmacology, pharmaceuticals, medicine, medical copy, medical copywriter, medical texts, medical books, medical textbooks, Elsevier, welters kluwer, medical journals, medical science, medical research, research, editorial journals, health, health translations, health writer, wellness, well-ness, psychology, psychiatric, internal medicine, neurology, oncology, genetics, genomics, nephrology, ophthalmology, medical education, medical training, clinical training, emt, md, phd, doctor, experience, veteran, expert, associate, senior, surgery. See less.
